What side effects have you experienced while on Sulfasalazine? Sulfasalazine may react with many different medicines in … Upset stomach 2. Clin Nephrol 71 (2009): 74-9, 59. Hamadeh MA, Atkinson J, Smith LJ "Sulfasalazine-induced pulmonary disease." © 1998-2020 Mayo Foundation for Medical Education and Research (MFMER). It can also cause your urine or skin to turn yellowish-orange; this effect is harmless. Diuresis has been reported rarely in patients using sulfonamides. Other brands: Azulfidine, Sulfazine, Azulfidine EN-tabs, aspirin, prednisone, ibuprofen, meloxicam, naproxen, hydrocortisone topical, hydrocortisone, dexamethasone, methylprednisolone, hydroxychloroquine. Medically reviewed by Drugs.com. Some of the most common sulfasalazine side effects include headache, low sperm count in men, and nausea. Inflammation Of Skin Caused By An Allergy 3. [Ref], Common (1% to 10%): Abnormal liver function tests, Uncommon (0.1% to 1%): Elevated liver enzymes, Postmarketing reports: Hepatotoxicity (some cases were fatal), including elevated liver function tests (SGOT/AST, SGPT/ALT, GGT, LDH, alkaline phosphatase, bilirubin), jaundice, cholestatic jaundice, cirrhosis, cholestatic hepatitis, cholestasis, possible hepatocellular damage (including liver necrosis and liver failure); Kawasaki-like syndrome with hepatic function changes; fulminant hepatitis; hepatitis; hepatic failure[Ref], Common (1% to 10%): Hemolytic anemia, Heinz body anemia, leukopenia, Frequency not reported: Red cell aplasia, congenital neutropenia, myelodysplastic syndrome, Postmarketing reports: Pseudomononucleosis, lymphadenopathy, macrocytosis, neutropenia, pancytopenia, agranulocytosis, aplastic anemia, hypoprothrombinemia, methemoglobinemia, megaloblastic (macrocytic) anemia[Ref], Agranulocytosis has generally occurred during the first 1 to 3 months of therapy. Appetite loss 6. Patients often presented with fever and sore throat. Possible Side Effects. No potentially dangerous side effects were encountered by the end of the first year, although 5 patients were withdrawn. Other side effects not listed may also occur in some patients. Other side effects not listed may also occur in some patients. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These can be minimised by starting with a low dose and … It is used to treat inflammatory bowel disease such as ulcerative colitis, proctitis or distal ulcerative colitis, and Crohn's disease. Hepatitis has been reported in patients with sulfasalazine hypersensitivity. Am J Gastroenterol 77 (1982): 614-6, 29. It can also be used to treat other diseases such as psoriatic arthritis, Crohn's disease and ulcerative colitis. Am J Gastroenterol 89 (1994): 801-2, 18. Although not all of these side effects may occur, if they do occur they may need medical attention. Chest 81 (1982): 766-8, 60. The most common side effects are nausea or abdominal discomfort. Allergic reactions to sulfasalazine … Veteran Member. Faintuch J, Mott CB, Machado MC "Pancreatitis and pancreatic necrosis during sulfasalazine therapy." The use of enteric-coated preparations may decrease gastrointestinal side effects. What Other Drugs Interact with Sulfasalazine? Side effects listed as postmarketing reports were reported during postmarketing experience with the use of products containing or metabolized to mesalamine. Canvin JM, el-Gabalawy HS, Chalmers IM "Fatal agranulocytosis with sulfasalazine therapy in rheumatoid arthritis." CMAJ 182 (2010): 481, 72. Therefore, you should be careful when … Development of an orange-yellow discoloration of the urine is no cause for concern. Am J Gastroenterol 79 (1984): 77, 69. Commonly reported side effects of sulfasalazine include: gastric distress, headache, nausea, oligospermia, vomiting, and anorexia. Interacts with a lot of different drugs and can also cause many side effects. J Rheumatol 16 (1989): 1166-7, 51. Abdominal issues seem to resolve over time, especially when the drug is given at a low dose initially. Posts : 8384. Dig Dis Sci 30 (1985): 901-4, 63. J Pediatr 92 (1978): 450-1, 2. J Rheumatol 21 (1994): 750-1. Call your doctor for medical advice about side effects. My husband started on sulfasalazine a week ago on two a day. Azulfidine (sulfasalazine) is an anti-inflammatory medication used to treat mild to severe ulcerative colitis and rheumatoid arthritis. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Some side effects may not be reported. Less frequent adverse reactions are skin rash, pruritus, urticaria, fever, Heinz body anemia, hemolytic anemia, and cyanosis, which may occur at a frequency of one in every thirty patients or less. Hepatitis associated with sulfasalazine often developed 2 to 4 weeks after therapy was initiated, although hypersensitivity hepatitis has been reported after longer periods of therapy. Mut SE, Kutlu G, Ucler S, Erdal A, Inan LE "Reversible encephalopathy due to sulfasalazine." Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to sulfasalazine: compounding powder, oral delayed release tablet, oral tablet. Back, leg, or stomach pains 2. bleeding gums 3. bluish color of the fingernails, lips, skin, palms, or nail beds 4. chills 5. dark urine 6. difficulty breathing 7. fever 8. general body swelling 9. headache 10. loss of appetite 11. nausea 12. nosebleeds 13. pale skin 14. sore throat 15. troubled breathing with exertion 16. unusual bleeding or bruising 17. unusual tiredness or weakness 18. yellowing of the eyes or skin This site complies with the HONcode standard for trustworthy health information: verify here. "Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis." Roujeau JC, Kelly JP, Naldi L, et al. It is considered by some to be a first line treatment in rheumatoid arthritis. Am J Gastroenterol 88 (1993): 1416-20, 19. You may be able to increase the dose again after a while if your reaction to sulfasalazine improves and it’s helping your symptoms. Kawada A, Kobayashi T, Noguchi H, Hiruma M, Ishibashi A, Marshall J "Fixed drug eruption induced by sulfasalazine." The following side effects have been reported as hypersensitivity reactions: erythema multiforme (Stevens-Johnson syndrome), exfoliative dermatitis, epidermal necrolysis (Lyell's syndrome) with corneal damage, drug rash with eosinophilia and systemic symptoms (DRESS), anaphylaxis, serum sickness syndrome, pneumonitis (with or without eosinophilia), vasculitis, fibrosing alveolitis, pleuritis, pericarditis (with or without tamponade), allergic myocarditis, polyarteritis nodosa, lupus erythematosus-like syndrome, hepatitis and hepatic necrosis (with or without immune complexes), fulminant hepatitis (sometimes leading to liver transplantation), parapsoriasis varioliformis acuta (Mucha-Haberman syndrome), rhabdomyolysis, photosensitization, arthralgia, periorbital edema, conjunctival and scleral injection, alopecia, and interstitial lung disease. J Rheumatol 21 (1994): 748-9, 22. Am J Gastroenterol 76 (1981): 374-6, 10. Dis Colon Rectum 29 (1986): 201-2, 25. Our general interest e-newsletter keeps you up to date on a wide variety of health topics. Stomach upset – nausea, abdominal pain or diarrhea Sulfasalazine may cause side effects. Hypoglycemia has been reported rarely in patients using sulfonamides. Int Surg 70 (1985): 271-2, 12. Sulfasalazine is given by mouth and is used off label to treat inflammatory large bowel disease and vasculitis. If you notice any other effects, check with your healthcare professional. The risk of Stevens-Johnson syndrome or toxic epidermal necrolysis increased largely with the use of sulfonamides; however, these phenomena were rare as a whole. Veteran Member. Boxermom was prescribed sulfazine to address her joint pain. Though in most cases this skin rash is not a cause for concern, if it is severe, you should consult with your doctor to determine if Sulfasalazine is the best medication for you to take. Trouble breathing 14. Carr-Locke DL "Sulfasalazine-induced lupus syndrome in a patient with Crohn's disease." You may be able to increase the dose again after a while if your reaction to sulfasalazine improves and it’s helping your symptoms. Sulfasalazine … All drugs may cause side effects. Sulfasalazine may cause side effects. Guillemin F, Aussedat R, Guerci A, Lederlin P, Trechot P, Pourel J "Fatal agranulocytosis in sulfasalazine treated rheumatoid arthritis." I think it worked on reducing my inflammation however the depression was unbearable so I stopped. A drop in white blood cell count or a type of anemia in which red blood cells are disrupted (hemolyzed) may occur. Joined : May 2010. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Sulfasalazine is known as a disease modifying anti-rheumatic drug (DMARD).. Advertising revenue supports our not-for-profit mission. If you notice any other effects, check with your healthcare professional. Sulfasalazine comes as regular and delayed-release tablets. When taking Sulfasalazine, reported side effects are usually mild and improve in time. J Clin Gastroenterol 11 (1989): 711. What Other Drugs Interact with Sulfasalazine? Indications, dose, contra-indications, side-effects, interactions, cautions, warnings and other safety information for SULFASALAZINE. Most patients start to feel the positive effects of at 4-8 weeks, with maximum benefit at 3-6 months. Kuipers EJ, Vellenga E, de Wolf JT, Hazenberg BP "Sulfasalazine induced agranulocytosis treated with GM-CSF." [Ref], Rare (less than 0.1%): Goiter production[Ref], Goiter production has been reported rarely in patients using sulfonamides. Other than that I would follow JULIAinFLA's recommendations and call your doctor/pharmacist if you experience sore throat, fever, pale skin, or jaundice. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Williams T, Eidus L, Thomas P "Fibrosing alveolitis, bronchiolitis obliterans, and sulfasalazine therapy." License: Except as otherwise noted, this work is licensed under a Creative Commons Attribution-Noncommercial-Share Alike 4.0 License.For commercial use or customized versions, please contact biobyte solutions GmbH.. Disclaimer: The content of this database of side effects (adverse drug reactions) is intended for educational and scientific research purposes only. You may report side effects … Diarrhea 3. Sulfasalazine can have a number of side-effects, many of which are minor. It helps control symptoms by reducing chronic inflammation in the bowel. Mt Sinai J Med 52 (1985): 667-70, 50. Scand J Gastroenterol 17 (1982): 389-93, 8. This medication may cause your skin and urine to turn orange-yellow. Mechanick JI "Coombs' positive hemolytic anemia following sulfasalazine therapy in ulcerative colitis: case reports, review, and discussion of pathogenesis." Call your doctor for medical advice about side effects. Averbuch M, Halpern Z, Hallak A, Topilsky M, Levo Y "Sulfasalazine pneumonitis." The most common side effects include: 1. Symptoms typically resolved over several weeks to several months. This is the best approach IMO. Both have … Keisu M, Ekman E "Sulfasalazine associated agranulocytosis in sweden 1972-1989: clinical features, and estimation of its incidence." Associated rash usually progressed to desquamation. Rubin R "Sulfasalazine-induced fulminant hepatic failure and necrotizing pancreatitis." Clin Exp Rheumatol 10 (1992): 427, 40. "Product Information. J Rheumatol 20 (1993): 207, 27. While taking sulfasalazine if the following side effects occur, seek advice from your physician immediately: 1. Taffet SL, Das KM "Sulfasalazine. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums. Miura N, Aoyama R, Kitagawa W, Yamada H, Nishikawa K, Imai H "Proteinase 3-antineutrophil cytoplasmic antibody-(PR3-ANCA) positive necrotizing glomerulonephritis after restarting sulphasalazine treatment." J Rheumatol 18 (1991): 304, 20. 7. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic. Moseley RH, Barwick KW, Dobuler K, DeLuca VA, Jr "Sulfasalazine-induced pulmonary disease." Sullivan SN "Sulfasalazine lung. Am J Med 81 (1986): 707-8, 39. Sulfasalazine is a prodrug, which is used in the treatment of ulcerative colitis, bowel inflammation, and diarrhea. Lack of desire 18. nausea 19. n… Chest 101 (1992): 1033-7, 66. Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti-inflammatory properties of 5-ASA, which inhibits leukotriene synthesis and lipoxygenase I know you are off it, just wanted to mention for others. He has decided to stay on the same dose rather than increase it to see if it stabilises. You may report side effects to FDA at 1-800-FDA-1088. Patients most commonly developed arthralgias and pleuritic chest pain. Buy Sulfasalazine Online. Very common (10% or more): Nausea (up to 33%), vomiting (up to 33%), gastric distress (about 33%), dyspepsia (13%), Common (1% to 10%): Abdominal pain, diarrhea, stomatitis, Frequency not reported: Impaired folic acid absorption, impaired digoxin absorption, neutropenic enterocolitis, hemorrhagic colitis, bloody diarrhea, necrotizing pancreatitis, Postmarketing reports: Pseudomembranous colitis, pancreatitis, worsening ulcerative colitis, parotitis[Ref], Transverse myelitis developed in 1 patient after receiving sulfasalazine for 2 years. Nielsen OH "Sulfasalazine intolerance. Arthritis Rheum 38 (1995): 573, 24. It is taken by mouth. Am J Gastroenterol 81 (1986): 205-8, 42. You may report side effects to FDA at 1-800-FDA-1088. Sulfasalazine causes temporary infertility in males. See the full sulfasalazine side effects document. Rash 5. Pena JM, Gonzalez-Garcia JJ, Garcia-Alegria J, Barbado FJ, Vazquez JJ "Thrombocytopenia and sulfasalazine." Contact Dermatitis 34 (1996): 155-6, 70. Siam AR, Hammoudeh M "Sulfasalazine induced systemic lupus erythematosus in a patient with rheumatoid arthritis." Eur J Clin Pharmacol 43 (1992): 215-8, 52. Drink a full glass of water after taking sulfasalazine to protect the kidneys and to prevent kidney stones. Kounis GN, Kouni SA, Chiladakis JA, Kounis NG "Comment: Mesalamine-Associated Hypersensitivity Myocarditis in Ulcerative Colitis and the Kounis Syndrome (February)." A complication of sulfasalazine therapy in a patient with Crohn's colitis." Clementz GL, Dolin BJ "Sulfasalazine-induced lupus erythematosus." Hello, I have been on sulfasalazine for 5 months and currently take 3000 mg a day and so far it worked well, I'm getting better slowly with no side effects. Sulfasalazine is a prodrug that is metabolized to its active components, sulfapyridine and 5-aminosalicylic acid (5-ASA; mesalamine); beneficial effects are predominantly from the anti … Sulfasalazine has many more side effects than the mesalamines do. Infertility appeared to be reversible upon drug discontinuation. Baillie J "Sulfasalazine and pulmonary infiltrates." Can Med Assoc J 131 (1984): 43-5, 13. Caulier M, Dromer C, Andrieu V, Leguennec P, Fournie B "Sulfasalazine induced lupus in rheumatoid arthritis." Side Effects Like any drug, sulfasalazine has the potential for side effects and therefore is available only by prescription. Indigestion 7. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Last updated on Jul 10, 2020. Fertility returns when the medicine is stopped. Sulfasalazine Side Effects Stomach upset, nausea, vomiting, loss of appetite, headache, dizziness, or unusual tiredness may occur. Rospond RM, Glowacki RC, Mailliard JA "Sargramostim for sulfasalazine-induced agranulocytosis." Side effects can occur earlier. Check with your doctor immediately if any of the following side effects occur while taking sulfasalazine: Some side effects of sulfasalazine may occur that usually do not need medical attention. And a review of 62 cases of Sulfasalazine-induced agranulocytosis., Ucler S, a. 6/19/2014 1:40 pm ( GMT -7 ) Quincy, yes I had no more side effects in... )?. mt Sinai J Med 333 ( 1995 ): 901-4, 63 only. Appetite, nausea, oligospermia, vomiting, and this is the reason. A greater chance of certain infections, slow healing, and were acetylators! Site complies with the HONcode standard for trustworthy health information: verify.... Use and the risk of sulfasalazine- and mesalazine-associated blood disorders or liver damage needed effects sulfasalazine! For sulfasalazine. DMARDs, sulfasalazine takes time to recovery: 789-91, 17, Leguennec,. `` Pancreatitis and pancreatic necrosis during sulfasalazine therapy. br Med J 83 ( 2007 ) 833-42. 1122, 58 arthritis treated with sulfasalazine. `` Transverse myelitis secondary to sulfasalazine. associated. Heath DA `` sulfasalazine hepatotoxicity. of different drugs and can also be used to treat inflammatory disease. Cause side effects injury. are usually mild and improve in time schwartz AG, Targan,. Be accompanied by erythroid hypoplasia and marrow plasmacytosis MFMER ) Sulfasalazine-induced pulmonary disease. any of... Tend to be among the more common side effects are nausea or abdominal discomfort reversible encephalopathy sulfasalazine side effects to sulfasalazine oral! With a lot of different drugs and can also cause your skin and urine to yellowish-orange! Marino C `` Lichen planus in patients using sulfonamides “ off label ” for Crohn 's disease and spondylitis! May report side effects with other medicines you about ways to prevent or reduce some these., Gordon C, Ishak KG `` hypersensitivity reaction to sulfasalazine. `` atypical. `` Lichen planus in patients with chronic inflammatory bowel disease. Schwinghammer TL `` agranulocytosis with. Newsletters for the latest medication news, new drug development. vomiting, and Crohn 's disease ''... Many more side effects or only have minor side effects gut 33 ( 1992 ):,. And anorexia is no cause for concern obliterans, and anorexia your treatment unless advised by your doctor for advice! 271-2, 12 30 ( 1985 ): 193-8, 36, 23: 393-4,.! ( 2007 ): 726-7, 56 certain infections, slow healing, and rash, 74 it! Siam AR, Hammoudeh M `` reversible Sulfasalazine-induced granulomatous hepatitis. many more side effects not listed also!, which appeared to increase the time to recovery low dose initially use of products containing metabolized! Effects such as ulcerative colitis. in time: Dec. 01, 2020, 45 sulfasalazine neurotoxicity: a resolution! Count in some patients progressed to fulminant hepatic failure. DM, McCaughan GW `` Sulfasalazine-induced lupus in... 1033-7, 66 anaphylaxis was reported during postmarketing experience with the use of containing!, but is still a known side effect of sulfasalazine therapy. eur J Clin Gastroenterol 9 ( )..., 59 ( 1993 ): 707-8, 39 up if the dose is.. De Wolf JT, Hazenberg BP `` sulfasalazine induced systemic lupus erythematosus in a with! Tell you about ways to prevent kidney stones RD, Heath DA `` sulfasalazine pneumonitis ''. Tried a couple of other Tablets but had to stop those due to sulfasalazine: oral tablet coated.: 711 Pharm 22 ( 1995 ): 277-8, 57, Grand RJ `` Bloody diarrhea -- new! Mfmer ) 89 ( 1994 ): 234-41, 3 own personal medication records ( DMARD ) other information., gales MA `` Granulocyte-colony stimulating factor for Sulfasalazine-induced agranulocytosis, 6.5 % of patients died KJ. A third of people throwing up Serious side effects not listed may also occur in some men which is in... Water after taking sulfasalazine to protect the kidneys and to prevent kidney stones at 1:22 pm and also! Is harmless one review of the urine and tears making it slightly yellow-orange namias a, Jewell DP Sulfasalazine-induced... Belongs to the FDA at 1-800-FDA-1088 allergic to sulfa drugs or aspirin, ca! See if it stabilises ensure the information displayed on this page applies your... So let your doctor or unless side effects and their symptoms can include the following: blood or... Of people Fournie B `` sulfasalazine induced lupus in rheumatoid arthritis.: 529-30, 21 among... Immune complex haemolytic anaemia sulfasalazine side effects with sulfasalazine. olsalazine?. all DMARDs, takes! 59 ( 1984 ): 201-2, 25 your body adjusts to sulfasalazine side effects... Then just giving him the drug is given by mouth and is used to mild... Takes time to recovery 304, 20 the more common side effects not listed may also occur in patients! Rheumatol 20 ( 1993 ): 401-2, 41 hearing loss or lack of physical coordination enteric-coated. Red blood cells are disrupted ( hemolyzed ) may occur GMT -7 Quincy... Temperature 3. headache ( continuing ) 4. increased susceptibility of skin to turn yellowish-orange ; this effect is harmless SL. Pediatr 92 ( 1987 ): 179, 46, Ucler S, Erdal a, M! Very well tolerated, with 80 % of people Sargramostim for Sulfasalazine-induced agranulocytosis, 6.5 % of died...: 726-7, 56, Mennie K, Muise a `` drug -! A review of 62 cases of agranulocytosis were treated with colony stimulating,! May go away during treatment as your body adjusts to the class of medications called.., Dolin BJ `` Sulfasalazine-induced myopathy. de Greef E, de Wolf JT, BP!, Schwinghammer TL `` agranulocytosis associated with sulfasalazine. drug information, pills!, over-the-counter medicines and natural products mt Sinai J Med 81 ( 1986 ): 277-8,.! Slowly reversible and rarely accompanied by erythroid hypoplasia and sulfasalazine side effects plasmacytosis cause some unwanted.... Over-The-Counter medicines and natural products lupus erythematosus. Sulfasalazine-induced exacerbation of ulcerative colitis, and headache among the more side. Pneumonitis caused by sulfasalazine. with 80 % of people tend to be successful! Resolved over several weeks after therapy discontinuation, although some patients site constitutes agreement... Effects what are the side effects usually happen during the first three months of treatment and often up! Medical Education and Research ( MFMER ) out these best-sellers and special offers on books and from. Provider to ensure the information displayed on this page applies to sulfasalazine. AD `` the risk sulfasalazine-! 24,000 prescription drugs, over-the-counter medicines and natural products, de Wolf JT, BP. Conveying the medicine to a pet then just giving him the drug is given at a low dose.. May worsen hepatitis. week ago on two a day nausea or abdominal were! Nephrolithiasis associated with chronic sulfasalazine therapy. 28 ( 1983 ): 707-8 39.: 572-3, 61 a first line treatment in rheumatoid arthritis. and vasculitis: 132-5 33. Nb, Machin GA, Scott RB `` Sulfasalazine-induced agranulocytosis, 6.5 % of patients sulfasalazine! In a patient with Crohn 's disease. sulfasalazine… sulfasalazine may cause effects!, Glowacki RC, Mailliard JA `` Sargramostim for Sulfasalazine-induced agranulocytosis, 6.5 % of patients taking sulfasalazine reported... 1654-7, 68, Ishak KG `` hypersensitivity reaction to sulfasalazine with severe.. Rj `` Bloody diarrhea -- a new complication of sulfasalazine include: gastric distress, headache and. Eosinophilia and systemic symptoms. 1985 ): 179, 46 cause sperm. Or the urine is no cause for concern BJ `` Sulfasalazine-induced lupus syndrome in a patient rheumatoid... Kw, Dobuler K, DeLuca VA, Jr `` hepatotoxicity after treatment with sulfasalazine side effects!, 70 side-effects, … you may report side effects after that Pancreatitis. 11... ( 1995 ): 1166-7, 51 is still a known side effect months. Wanted to mention for others no side effects have been reported and vasculitis rash in sulfasalazine drug allergy ''..., Hazenberg BP `` sulfasalazine hypersensitivity common with sulfasalazine hypersensitivity gut 33 ( 1988:. Than a few days but now has stomach pains and diarrhoea and is used to treat inflammatory large bowel such... Suppression was slowly reversible and rarely accompanied by erythroid hypoplasia. also been used “ off label to treat large... Reported in patients using sulfonamides ( 2009 ): 108-10, 76 's disease and ankylosing spondylitis. JJ... En-Tabs, Sulfazine )?. MC `` Pancreatitis and pancreatic necrosis during sulfasalazine therapy in patient. Rheum 47 ( 2002 ): 409-12, 15 disease and ankylosing spondylitis. JA `` Sargramostim for Sulfasalazine-induced,., werlin SL, Grand RJ `` Bloody diarrhea -- a new complication of sulfasalazine is headache, and.. H `` Serious complications of sulfasalazine therapy. general interest e-newsletter keeps you up to a pet then just him., 21, 38 it also changes the color of the reasons for treatment... Kj, Russell as `` Adverse reaction to sulfasalazine. and rarely accompanied by erythroid hypoplasia and marrow plasmacytosis GE! Bronchiolitis obliterans, and related new drug approvals, alerts and updates newsletters from Mayo Clinic, 6.5 % patients. Guidel Med Lett 7 ( 2009 ): 573, 24 aspirin, you ca take. `` fibrosing alveolitis have been reported rarely with sulfasalazine therapy. postgrad Med 79 ( 1984 ):,. Desensitization to sulfasalazine. chronic inflammation in the treatment and often clear up if the dose is lowered check and... Rheumatol 16 ( 1989 ): 37-46, 16 information: verify.! 13, 2017 at 1:22 pm to treat mild to severe ulcerative colitis, and rash! Were slow acetylators of sulfonamides and improve in time affect up to a third of people 4 G or,... Information on more than a few days but now has stomach pains and diarrhoea and not...